Endocrine Abstracts

Introduction: Immune tumor microenvironment plays a key role in tumors’ growth and metastatic spread, while its role in the heterogeneous field of neuroendocrine neoplasms (NENs) remains unclear. There is evidence that tumor progression in NENs is promoted by an immunosuppressed microenvironment created by a plethora of infiltrating immune cells. Changes in circulating leukocyte and peripheral blood mononuclear cell (PBMC) subpopulations can mirror the local alteration of...

Background: Bilateral testicular germ cell tumors (B-TCGT) are reported as rare findings (incidence 1-8%) and can be distinguish in synchronous (sB-TCGT) (recurrence within 3 months) and metachronous (mB-TCGT) (recurrence after 3 months). Risk factors of relapse are still underexplored. The aim of our study was to identify clinical, biochemical and radiological risk factors for the onset of a second tumor in a wide cohort of TGCT patients. Materials and ...